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Ren-He Xu, M.D., Ph.D.

Xu Lab

 
     
 
PUBLICATIONS
 

Wang X, Lin G, Marings-Taylor K, Zeng H, and Xu RH, Inhibition of caspase-mediated anoikis is critical for bFGF-sustained culture of human pluripotent stem cells. J Biol Chem. 2009 Oct 16.

Li Y, Zeng H, Xu RH, Liu B, Li Z.Vaccination with Human Pluripotent Stem Cells Generates a Broad Spectrum of Immunological and Clinical Response against Colon Cancer.Stem Cells. 2009 Oct 8.

Zeng H, Park JW, Guo M, Lin G, Crandall L, Compton T, Wang X, Li XJ, Chen FP, Xu RH., Lack of ABCG2 Expression and Side Population Properties in Human Pluripotent Stem Cells. Stem Cells. 2009 Aug 7;27(10):2435-2445.

Xie, C.-Q., Jeong, Y., Fu, M. Bookout, A.L., Garcia-Barrio, M.T., Sun, T., Kim, B.-h., Xie, Y., Root, S., Zhang, J., Xu, R.-H., Chen, Y.E., and Mangelsdorf, D.J. Expression profiling of nuclear receptors in human and mouse embryonic stem cells. Mol. Endocrinol. Feb. 5, 2009.
 
Zhou, J., Xu, R.-H., and Wang Y. Nanoporous membrane-encapsulated feeder cells for culture of human embryonic stem cells. Int’l J. Functional Informatics & Personalized Med. 2(1):77-88, 2009.

Wang, S., Shen, Y., Yuan, X., Chen, K., Guo, X., Chen, Y., Niu, Y., Li, J., Xu, R.-H., Yan X., and Ji, W. Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells. J. Biol. Chem. 283(51):35929-40, 2008.

Xu, R.-H., Sampsell-Barron, T.L., Gu, F., Root, S., Peck, R.M., Pan, G., Yu, J., Antosiewicz-Bourget, J., Tian, S., Stewart, and Thomson, J.A. NANOG is a direct target of TGFb/Activin mediated SMAD signaling in human ES cells. Cell Stem Cell. 3(2):196-206, 2008.   

Shen, Y., Matsuno, Y., Fouse, S.D., Rao, N., Root, S., Xu, R.-H., Pellegrini, M., Riggs, A.D., and Fan, G. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alternations. Proc. Natl. Acad. Sci. U.S.A. 105(12):4709-14, 2008.

Peng, Y., Yang, P.-H., Tanner, J.A., Huang, J.-D., Li, M., Lee, H.F., Xu, R.-H., Kung, H.-F., and Lin, M.C. Cold-Inducible RNA Binding Protein is Required for the Expression of Adhesion Molecules and Embryonic Cell Movement in Xenopus Laevis. Biochem. Biophys. Res. Commun. 344(1):416-24, 2006.

Levenstein, M.E., Ludwig, T.E., Xu, R.-H., Llanas, R.A., VanDenHeuvel-Kramer, K., Manning, D., and Thomson, J.A. Basic FGF support of human embryonic stem cell self-renewal. Stem Cells 24(3):568-74, 2006.

Xu, R.-H., Peck, R.M., Li, D.S., Feng, X., Ludwig, T., and Thomson, J.A. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods 2(3):185-190, 2005.


Xu, R.-H. In vitro induction of trophoblast from human embryonic stem cells. In Michael J. Soares ed. Placental and trophoblast methods and protocols for Methods in Molecular Medicine Series. Humana Press, Inc. Totowa, NJ, pp189-202, 2005.


Golos, T. and Xu, R.-H. Trophoblast differentiation from embryonic stem cells. In Ordorico, J., Pedersen, R., and Zhang, S.-C. ed. Human embryonic stem cells. BIOS Scientific Publishers Ltd., Oxford, U.K., pp101-120, 2005.


Xu, R.-H., Chen, X., Li, D.S., Li, R., Addicks, G.C., Glennon, C., Zwaka, T.P., and Thomson, J.A.  BMP4 initiates human embryonic stem cell differentiation to trophoblast.  Nat. Biotech. 20(12):1261-4, 2002.


Peng, Y., Xu, R.-H. (equal first author), Mei, J.M., Li, X.-P., Yan, D.-H., Kung, H.-f., and Phang, J.M.  Neural inhibition by c-Jun as a synergizing factor in BMP-4 signaling.  Neurosciece 109(4):657-64, 2002.


Peng, Y., Kok, K.H., Xu, R.-H., Kwok, K.H.H., Fung, P.C.W., Kung, H.-f., and Lin, M.C.M.  Maternal cold inducible RNA binding protein is required for Xenopus laevis embryonic kidney formation.  FEBS Letter.  24130:1-7, 2000.


Xu, R.-H.,  Peng, Y., Fan, J., Yan, D.-H., Yamagoe, S., Princler, G., Sredni, D., Ozato, K., and Kung, H.-f.  Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction.  Dev. Dyn.  218:628-635, 2000.


Kim J., Lee, H.-S., Roh, D.-H., Hwang, Y.-S., Xu, R.-H., Kung, H.-f., Bae, Y.-C., and Mae-Ja Park.  Transcriptional regulation of the Xbr-1a/Xvent-2 gene by BMP-4 signaling during Xenopus embryonic development.  Korean J. Anatomy 33:595-608, 2000.


Liu, W., Ren, C., Shi, J., Feng, X., He, Z., Xu, L., Lan, K., Xie, L., Peng, Y., Fan, J., Kung, H.-f., Yao, K.-T., and Xu, R.-H.  Characterization of the functionally related sites in the neural inducing gene noggin. Biochem. Biophys. Res. Commun. 270:293-297, 2000.


Xu, R.-H., Lechleider, R.J., Shih, H.-M., Hao, C.-F., Sredni, D., Roberts, A.B., and Kung, H.-f.  Functional analysis of human Smad1: role of the amino-terminal domain. Biochem. Biophys. Res. Commun. 258:366-373, 1999.


Xu, R.-H., Ault, K.T., Kim, J., Park, M.-J., Hwang, Y.-S., Peng, Y., Sredni, D., and Kung, H.-f.  Opposite effects of FGF and BMP-4 on embryonic blood formation: roles of PV.1 and GATA-2.  Dev. Biol. 208:352-361, 1999.


Kim, J., Ault, K.T., Chen, H.-D., Xu, R.-H., Roh, D.-H., Lin, M.C., Park, M.-J., and Kung, H.-f.  Transcriptional regulation of BMP-4 in the Xenopus embryo; analysis of genomic BMP-4 and its promoter.  Biochem. Biophys. Res. Commun.  250:516-530, 1998.


Rosenblatt-Bin, H., Kalechman, Y., Vonsover, A., Xu, R.-H., Da, J.-P., Shalit, F., Huberman, M., Klein, A., Strassmann, G., Albeck, M., and Sredni, B. The immunomodulator AS101 restores T(H1) type of response suppressed by Babesia rodhaini in BALB/c mice.  Cell Immunol. 184:12-25, 1998.


Kamata, T., Daar, I.O., Subleski, M., Copeland, T., Kung, H.-f., and Xu, R.-H. Xenopus CRMP-2 is an early response gene to nerual induction.  Mol. Brain Res. 57:201-210, 1998.


Jones, T., Chong, L.D., Kim, J., Xu, R.-H., Kung, H.-f., and Daar, I.O.  Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of Xlerk, an erythropoietic producing hepatocellular ligand.  Proc. Natl. Acad. Sci. U.S.A. 95:576-581, 1998.


Kim, J., Lin, J-J., Xu, R-H. and Kung, H-F.  Mesoderm induction by Heterodimer AP-1 (c-Jun and c-Fos) and its involvement in mesoderm formation through Xbra/eFGF autocatalytic loop during the early development of Xenopus embryos.  J. Biol. Chem. 273:1542-1550, 1997.


Ault, K.T., Xu, R.-H.(eaqual first author), Kung, H.-F., and Jamrich, M.  The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos.  Dev. Biol. 192:162-171, 1997.


Xu, R-H., Kim, J., Taira, M., Sredni, M. and Kung, H-f.  Studies on the role of fibroblast growth factor signaling in neurogenesis using conjugated/aged animal caps and dorsal ectoderm-grafted embryos.  J. Neurosci. 17:6892-6898, 1997.


Xu, R.-H., Kim, J., Taira, M., Lin, J.-J., Zhang, C.-h., Sredni, D., Evans, T., and Kung, H.-f.:  Differential regulation of neurogenesis by the two Xenopus GATA-1 genes.  Mol. Cell. Biol. 17:436-443, 1997.


Maeno, M., Mead, P.E., Kelly, C., Xu, R.-H., Kung, H.-f., Suzuki, A., Ueno, N., and Zon, L.I.: The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis.  Blood 88:1965-1972, 1996.


Xu, R.-H., Kalechman, Y., Albeck, M., Kung, H.-f., and Sredni, B.: Inhibition of B16 melanoma metastasis by the immunomodulator AS101.  Int. J. Oncol. 9:319-325, 1996.


Dong, Z., Xu, R.-H. (eaqual first author), Kim, J., Zhan, S., Ma, W., Colburn, N.H., and Kung, H.-f.: AP-l/Jun is required for early Xenopus development and mediates themesoderm induction by FGF but not by activin. J. Biol. Chem. 271:9942-9946, 1996.


Sredni, B., Xu, R.-H., Albeck, M., Gafter, U., Gal, R., Shani, A., Tichler, T.,  Shapira, J., Bruderman, I., Catane, R., Kaufman, B., Whisnanty, J.K., Mettinger,  K.L., and Kalechman, Y.: The protective role of the immunomodulator AS101 against  chemotherapy-induced alopecia. Studies on human and animal models. Int. J. Cancer 65:97-103, 1996.


Xu, R.-H., Dong, Z., Maeno, M., Kim, J., Suzuki, A., Ueno, N., Sredni, B., Colburn, N.H., and Kung, H.-f.: Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development.  Proc. Natl. Acad. Sci. U.S.A.  93:834-838, 1996.


Xu, R.-H., Kim, J., Taira, M., Zhan, S., Sredni, D., and Kung, H.-f.:  A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm.  Biochem. Biophys. Res. Commun. 212:212-219, 1995.

 

 

 
 
LAB MEMBERS
 
Ren-He Xu Principal Investigator  
Leann Crandall Research Associate and Manager
Tiwanna Campton Research Assistant II
Jung Woo Park Research Assistant
Kristen Martins-Taylor Postdoctoral Fellow
Feng Gu Postdoctoral Fellow
Ge Lin Postdoctoral Fellow
Hui Zeng Visiting Student
Vanessa Piccuillo Rotation Student
ROTATIONS

Students are welcome to our lab to learn technologies related to human embryonic stem cells, which may expand their career choices through combination of these cutting-edge technologies with others. There are also pilot as well as ongoing projects in our lab that are suitable for short-term rotations and potentially long-term studies.

Please contact Dr. Xu to discuss about these opportunities.