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Kazuya Machida, Ph.D., M.D.

Machida Lab


PUBLICATIONS

Machida, K., and B.J. Mayer. 2005. The SH2 domain: versatile signaling module and pharmaceutical target. Biochim Biophys Acta 1747:1-25.

Takenouchi, Y., M.L. Oo, T. Senga, Y. Watanabe, K. Machida, K. Miyazaki, Y. Nimura, and M. Hamaguchi. 2004. Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells. Oncol Rep 11:1059-1062.

Machida, K., B.J. Mayer, and P. Nollau. 2003. Profiling the global tyrosine phosphorylation state. Mol Cell Proteomics 2:215-233.

Zhang, Y., A.A. Thant, K. Machida, Y. Ichigotani, Y. Naito, Y. Hiraiwa, T. Senga, Y. Sohara, S. Matsuda, and M. Hamaguchi. 2002. Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90. Cancer Res 62:3962-3965.

Ruhul Amin, A.R., K. Machida, K. Oshima, M.L. Oo, A.A. Thant, T. Senga, S. Matsuda, A.A. Akhand, A. Maeda, T. Kurosaki, and M. Hamaguchi. 2002. A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling. Oncogene 21:8871-8878.

Oshima, K., K. Machida, Y. Ichigotani, Y. Nimura, N. Shirafuji, M. Hamaguchi, and S. Matsuda. 2002. SHPS-1: a budding molecule against cancer dissemination. Cancer Res 62:3929-3933.

Sohara, Y., N. Ishiguro, K. Machida, H. Kurata, A.A. Thant, T. Senga, S. Matsuda, K. Kimata, H. Iwata, and M. Hamaguchi. 2001. Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner. Mol Biol Cell 12:1859-1868.

Hayashi, K., S. Matsuda, K. Machida, T. Yamamoto, Y. Fukuda, Y. Nimura, T. Hayakawa, and M. Hamaguchi. 2001. Invasion activating caveolin-1 mutation in human scirrhous breast cancers. Cancer Res 61:2361-2364.

Senga, T., K. Miyazaki, K. Machida, H. Iwata, S. Matsuda, I. Nakashima, and M. Hamaguchi. 2000. Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A. Oncogene 19:273-279.

Matsuda, S., R. Katsumata, T. Okuda, T. Yamamoto, K. Miyazaki, T. Senga, K. Machida, A.A. Thant, S. Nakatsugawa, and M. Hamaguchi. 2000. Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer. Cancer Res 60:13-17.

Machida, K., S. Matsuda, K. Yamaki, T. Senga, A.A. Thant, H. Kurata, K. Miyazaki, K. Hayashi, T. Okuda, T. Kitamura, T. Hayakawa, and M. Hamaguchi. 2000. v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells. Oncogene 19:1710-1718.

Kamei, T., K. Machida, Y. Nimura, T. Senga, I. Yamada, S. Yoshii, S. Matsuda, and M. Hamaguchi. 2000. C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner. Int J Oncol 17:335-339.

Ichigotani, Y., S. Matsuda, K. Machida, K. Oshima, T. Iwamoto, K. Yamaki, T. Hayakawa, and M. Hamaguchi. 2000. Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family. J Hum Genet 45:378-382.

Thant, A.A., T.T. Sein, E. Liu, K. Machida, F. Kikkawa, T. Koike, M. Seiki, S. Matsuda, and M. Hamaguchi. 1999. Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1. Oncogene 18:6555-6563.

Serbulea, M., S. Kakumu, A.A. Thant, K. Miyazaki, K. Machida, T. Senga, S. Ohta, K. Yoshioka, N. Hotta, and M. Hamaguchi. 1999. Hyaluronan activates mitogen-activated protein kinase via Ras-signaling pathway. Int J Oncol 14:733-738.

Miyazaki, K., T. Senga, S. Matsuda, M. Tanaka, K. Machida, Y. Takenouchi, Y. Nimura, and M. Hamaguchi. 1999. Critical amino acid substitutions in the Src SH3 domain that convert c-Src to be oncogenic. Biochem Biophys Res Commun 263:759-764.

Wang, X., A.A. Thant, K. Machida, Y. Hiraiwa, H. Iwata, S. Matsuda, and M. Hamaguchi. 1998. Suppression of cell growth by ectopic expression of N-cadherin. Int J Oncol 12:1097-1101.

Hamaguchi, M., X.D. Wang, K. Machida, and Y. Itoh. 1997. Cell transformation by Src kinase: role of cell adhesion system as a signal transducer. Tanpakushitsu Kakusan Koso 42:1687-1693.

Nishimura, M., K. Machida, M. Imaizumi, T. Abe, T. Umeda, E. Takeshima, T. Watanabe, Y. Ohnishi, K. Takagi, and M. Hamaguchi. 1996. Tyrosine phosphorylation of 100-130 kDa proteins in lung cancer correlates with poor prognosis. Br J Cancer 74:780-787.

Machida, K., K. Takagi, and M. Horiba. 1996. Thromboxane A2 synthetase inhibitor in asthma therapy. Nippon Rinsho 54:3034-3039.

Ando, M., M. Horiba, T. Sumita, J. Shindo, K. Machida, and K. Takagi. 1995. Home days ratio in patients treated with long-term oxygen therapy. Nihon Kyobu Shikkan Gakkai Zasshi 33:1086-1092.

 

 

 
LAB MEMBERS
Kazuya Machida, Principal Investigator

 

 
ROTATIONS

Coming soon.