Hormonal regulation of bone remodeling.

The major interest of our laboratory is to elucidate the mechanisms by which hormones and growth factors regulate bone remodeling in postnatal life, with an emphasis on the development and characterization of transgenic and mutant mouse models. Our current projects include studying the roles of insulin-like growth factor (IGF-I) and glucocorticoids on bone remodeling, and examining the role that a dominant negative member of the CREM transcription factor family plays in parathyroid hormone-dependent gene expression in osteoblasts.